First, this article was written in sections, to facilitate the reader experience. Some sections has a compacted information, other more specific details in neuroscience or engineering. It is totally up to the readergo thru all the sections or not. For completely understanding of the technology and applications mentioned on title, the author truly recommends to read the hole structure.
This section presents the main idea of the neurological system, introducing the action potential theory, neuron structures, etc.
本节介绍神经系统的主要思想,介绍动作电位理论,神经元结构等。
There are 86 billion neuron cells in typical human brain. Neurons send and receive information. Although neurons come in many different types, they generally have three parts: a dendrite which receives a signal, a cell body called soma which computes the signal, and an axon which sends a signal out.
Neurons are connected through synapses. The neurons of the brain connect to each other to send and receive signals through axon-dendrite connections called synapses.
神经元通过突触连接。 通过轴突-树突连接,大脑的神经元相互连接,发送和接收信号。
Neurons communicate through electric signals. cause synapses to release neurotransmitters. These small molecules bind to receptors on dendrites, opening channels that cause current to flow across the neuron’s membrane. When a neuron receives the ‘right’ combination of spatiotemporal synaptic input, it initiates an action potential.
It’s possible to record electrical signals in the brain. To get this,electrodes should be placednear neurons in order to detect action potentials. Recording from many neurons, allows to decode the information represented by those cells. There are neurons in the brain that carry information about everything we see, feel, touch, or think.
This section presents the notion of the importance of the future technology applied in medicine, more precisely in engineering of the brain.
本节介绍了未来技术在医学中的重要性。
When speaking about technology in healthcare, specially orientated to hardware systems, it talks about biomedical engineering. Instrumentation, controlling, automation, sensing and etc, are the main fields to create a new technology in medicine, f.e., robotics (this include prosthesis, bionic members, electromyographs), machines for image diagnosis (ultrasound scan, MRI), andhuman sensors (pulse oximeter, electrodes).
Neural engineering is a branch of biomedical engineering and by it’scomplexity, is totally acceptable that, everything from electrical engineering, neuroscience, biochemistry and others subjects, is all compacted into it. Getting start on electrical engineering point, since simulations to manufacture the first prototype, is required a hard mathematical modeling, conditioning circuit, signal processing, power supply effectiveness, study on interference based on electromagnetic dynamics, simulations and etc. After that itmust be integrated with the other areas to be acceptable. It is not that simple.
Neural engineers are interested in understanding, interfacing with and manipulating the nervous system. (…) One benefit of understanding this communication is to provide new ways to interface between neural tissue and manmade technologies. This is known as brain-machine interfacing. IEEE(EMB)
But let’s suppose that the idea is feasible. Imagine a implanted device inside a head that could detect electrical signal from human body, specially on brain, neurological signals, brainstem connections, and thespinal system. Imagine that it can process visual, audition, motor activating sensor signals on this device. After that, picture this kind of tiny electrode applying an ideal and controlled stimuli pulse for a compromised neural network, the exactly network that is responsible for the movement of a body member, or touch sense, visual network, and turning the paraplegic patient able to doa step, or a blind into a watcher, or people with communication problems into speakers. Even more, send all those signals, responses, wireless to a computer, from the skin.
I can say that this is totally getting out of the “paper” and going to some “heads”. Yes, and it is not a brand new Black Mirror episode.
我可以说这完全摆脱了“纸面”,走向了某些“头脑”。 是的,这不是全新的《 黑镜》剧集。
Elon Musk is beginning a new era of neural engineering. Not impossible for who’s already CEO of, a smart space rocket industry (SpaceX), and a robust, powerfull and effective vehicles industry (Tesla). He reveled Neuralink’s plans for brain-reading “threads” and a robot to insert them in a online Conference (August, 2020).
Neuralink develops and approaches the idea behind the, brain-machine interface () or similar to brain computer interface () either. Instead of (Electroencephalogram), a non invasive method for neural monitoring, that results in blurred signals (mostly because of detecting difficulties), Neuralink shows the invasive model more effective, handling with secure and body compatibility.
Actually, Elon is the Neuralink founder and majority owner of the company, but the CEO is Jared Birchall.
实际上, 埃隆(Elon)是Neuralink的创始人和大股东,但首席执行官是贾里德·比尔查尔 ( Jared Birchall) 。
Neuralink概述 (Neuralink Overview)
This section shows the overview of the structures of the Neuralink technology.
本节概述了Neuralink技术的结构。
Compared to the link of the last year (2019), the new device got some improvements. One to highlight isthe recharging evolution.
与去年( 2019年 )的链接相比,新设备进行了一些改进。 值得一提的是充电的发展。
Electrodes — hassame size scale as neighboring neurons and as flexible as possible; there are a dozens of electrodes in a (a signal conductor and insulator of 43 millilitres long and totally flexible); microfabricationof thethreadsresultsthin film metals and polymers resistant to corrosion from fluid in the tissue; it must have sufficient surface area to allow stimulation;
Chips — the Link of Neuralink needs to convert the small electrical signals (microvolts) recorded by each electrode into real-time neural information; it must have high-performance signal amplifiers and digitizers;
Packaging —Link needs to be protected from the fluid and salts that bathe surrounding tissue on brain; it’s very hard when that enclosure must be constructed from biocompatible materials; multiple components with a process that builds them as a single component is presented;
Neurosurgery — the threads are too thinto be manipulated by hand and too flexible to go into the brain on their own (imagine trying to sew a button with thread but no needle); it needs to safely insert them with precision and efficiency; the solution is based on a new kind of surgical robot.
Threads, which are smaller than human hair and are 4 to 6 micrometers in diameter, can transfer huge amounts of data, and 32 threads contain 1024 electrodes per array.
小于人类头发且直径为4至6微米的线程可以传输大量数据,并且32个线程每个阵列包含1024个电极。
neuralink.com) Neuroink.com )
The Neuralink chip has the inductive charge method. To get the Neuralink, the robot puts in the electrodes and do the automated surgery in less than one hour, making the patient possible to leave the hospital in the same day and without general anesthesia.
The first thing that Link will do is detect neurons activity, by usingsignal processing to control an outside computer. As the users thinkabout moving their arms or hands, it could decode those intentions, which would be sent over Bluetooth to the user’s computer interface.
We plan to help people with severe spinal cord injury by giving them the ability to control computers and mobile devices directly with their brains. Neuralink
我们计划通过使他们能够直接用大脑控制计算机和移动设备的方式来帮助患有严重脊髓损伤的人。 神经链
实验 (Experiment)
This section shows three important experiments with three pigs (very similar structures to human brain) done at the last Neuralink conference presented by Elon Musk.
The first experiment shows that the first pig, Dorothy, remains healthy and happy, after an implant removing procedure as a result of a factual reversibility of the chip.
第一个实验表明,由于芯片的事实可逆性,在去除植入物后,第一只猪多萝西保持健康快乐。
The second experiment shows the spikes and sounds bips of neural connection with the chip. When the other pig, Gertrude,snuffles around and touches something with her nose. The blue wave at the figure below, shows the accumulative spikes of activation from electrodes connections with neurons, in white dots, on time. Gertrude had been with the link over two months, with health.
The last one shows the comparison of the measured motor activity and the predicted with computer vision of the shoulder, elbow, carpal and trotter joints, in order, of the pig in a treadmill. Yes, a pig on a treadmill!
The experiment results shows the good functionality of the implanted system.
实验结果表明该植入系统具有良好的功能。
Neuralink详细 (Neuralink Detailed)
This section shows a detailed information from Neuralink chip operation modeling, in terms of hardware and software functionality. It will detail startingfrom the “macro” to the micro way point of view.
The first Neuralink project is the detection. As the neuron fires, the spike (or action potentials) connects to one of the 1024 electrodes channels. The pulse needs to flow into a pass band filter (instead of a time domain, there is a frequency domain, so there is a band width frequency range of the neural spike that needs to remain) to exclude noise signals.
For a better manipulating, this filtered signal needs to be amplified digitized by an analog to digital converter (). After processing it on internal microprocessor, the signal must be converted in digital to analog andfinally amplified bewireless transmited, as Neuralink engineers confirm, Bluetooth low energy radiofrequency ().
The following image illustrate a simplified flowchart (from the author’s point of view) for the signal and the small idea of BCI initial process (neural detection and stimulation process).
下图说明了信号的简化流程图(从作者的角度来看)和BCI初始过程(神经检测和刺激过程)的小思路。
Scheme-It) Scheme-It上编辑)
Some additional blocks could be included in the chart. For example, in the process before thetransmission switch, could be mixed an oscillator, with the output amplified signal, for a better signal modulation in a specific frequency. This procedure allows a better telecommunication signal processing, in terms of power and signal-to-noise factor. Or even a conditioning circuitry block for power supply. For simplicity, are not included such specifications on theflowchart.
All the process in the flowchart in terms of sensing, amplification, conversion, and processing, aretotally integrated on N1 chip of the Neuralink. N1 is a totally customized ASIC (Application Specific Integrated Circuits) for the brains specifications, assuming that there is nothing on market that provides such features, as neural amplifiers f.e.
The ADC divides the magnitude of each piece in 1024 levels, so N1 has 10 bits of resolution (as the digitized conversion is only about ‘1’ and ‘0’, total bits is 2¹⁰ = 1024). The detection process duration is, 900 nanoseconds (0.0000009s), and this is determined by the internal clock of the N1. Considering neural speed communication, everything on Link happens faster than the brain!
ADC将每段的幅度划分为1024个级别,因此N1具有10位分辨率( 由于数字化转换仅约为'1'和'0',所以总位为2 1 = 1024 )。 在检测过程中持续时间为,900个纳秒(0.0000009s),并且这是由N1的内部时钟确定。 考虑到神经速度交流, Lin k上的所有事物发生的速度都比大脑快!
Image: Neuralink (2019)
图片:Neuralink(2019)
The entire Neuralink measures 23 x 8 mm. Going inside of N1SOC (System-On-Chip), that has 5 x 4 mm, it’s possible to find 1024 channels for all electrodes. Each channel has a noise correction factor of 7.2 micro Volts. For each thread channel there is a analog pixel with 6.6 micro Wattsof power consummation.
整个Neuralink尺寸为23 x 8毫米 。 进入具有5 x 4 mm的N1SOC (片上系统 )的内部,可以为所有电极找到1024个通道。 每个通道的噪声校正系数为7.2微伏 。 对于每个线程通道,都有一个功耗为6.6微瓦的模拟像素。
CNET) CNET )
Over time, Neuralink improved three version revisions of the analog pixel, in size, power consumption while maintaining itsperformance. The last version on the right, (see figure below), is five times smaller than the known state of the art. Each pixel is dedicated to each electrode, as published on academic literature.
Let’s zoom in more, going from the analog pixel channel thru the thread with the electrodes. A hair has a 100 microns of diameter, the thread called linear edge, has the electrodes,whereas each one has 5 microns! Neuralink made over 20 designs of the threads, and the goal was to increase the number of the electrode at each channel, without significantly increase the width of these threads at the base (see figure below).
However, as the number of electrodes increases, these raw digital signals become too much information to upload with low power devices, and, in this case, N1 essentially saturates in signal processing, and may cause wrong measurements and overheating f.e.
The surgery robot must precisely dothe incision and implant exactly on specific spots that do not harm the bloodtream.
手术机器人必须精确地做 准确地将切口和植入物植入不会损害血流的特定部位。
Blomberg Technology) Blomberg Technology )
Speaking on software, there isn’t one programming language describing all algorithm for the Link and the surgery robot. To have an idea, at the low levels chip programming, in terms of the registers and peripherals structures, it uses Verilog, but it also uses C, C++, Python, Java…
在软件方面,没有一种编程语言可以描述Link和手术机器人的所有算法。 可以想见,在低级芯片编程方面,就寄存器和外设结构而言,它使用Verilog ,但也使用C , C ++ , Python,Java…
最后考虑 (Final Considerations)
This section presents some considerations about Neuralink future visions and author’s opinion.
本节介绍有关Neuralink未来愿景和作者观点的一些考虑。
Control or insulate the brain electric field of the entire implant ought to be accomplished, even detecting spikes or stimulating them; 控制或隔离整个植入物的脑部电场应该完成,甚至可以检测或刺激峰值。
Decrease material resistance for cleaner detection, as electrode detects the action potential spikes. This procedure will optimize the filter and amplifier; 减少电极的电阻,以进行更清洁的检测,因为电极可以检测到动作电位尖峰。 此过程将优化滤波器和放大器。
Decreasing the thickness of the electrode is a huge gain, but it results in a reduction in the cross-section of a conductor, directly influencing the flow of electrical current. So the main objective is to optimize these correlated functions; 减小电极的厚度是一个巨大的进步,但它会导致导体横截面的减小,从而直接影响电流的流动。 因此,主要目标是优化这些相关功能。
Elon Musk revealed that, Link including surgery procedure, it will cost a few thousand dollars and will decrease it over time;
One thing to prevent is the internal and external interference, such that sealing the Link package must beas better as it can possible, mainly the electronic circuit insulation;
In conference was discussed that in future it will possible to make a backup and replay the memories. In additional, probably will be able to export communication that is hard to expose, like ideas, engineering models, art, music, using f.e. augmented reality; 在会议上讨论的是,将来有可能进行备份并重播回忆。 此外,可能还可以使用增强现实技术导出难以公开的交流,例如思想,工程模型,艺术,音乐。
Put an end on diseases (control chemical, enzymes productions), cure anxiety, depression, autism, and etc. 终结疾病(控制化学物质,酶的产生),治愈焦虑症,抑郁症,自闭症等。
The Neuralink will process the external cortex, in special motor, sensing, vision, auditory, and language areas. But when talking about emotions, consciousness, psychological behavior, at the moment, will be limited to detect and study. Those are located in profound regions, like hypothalamus. To reach these regions isn’t reasonable just extend a thread. Other scientists present on the conference related that brain movements, physical impacts, and the hole structure must be studied. But it is possible. Neuralink将处理特殊运动,感觉,视觉,听觉和语言区域中的外部皮层。 但是,当谈及情感时,目前意识,心理行为仅限于发现和研究。 那些位于下丘脑等深远的区域。 要到达这些区域是不合理的,只需扩展一个线程即可。 与会的其他科学家认为,必须研究大脑的运动,物理影响和Kong结构。 但是有可能。